| Title | Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Mark T, Stern J, Furst JR, Jayabalan D, Zafar F, Larow A, Pearse RN, Harpel J, Shore T, Schuster MW, Leonard JP, Christos PJ, Coleman M, Niesvizky R |
| Journal | Biol Blood Marrow Transplant |
| Volume | 14 |
| Issue | 7 |
| Pagination | 795-8 |
| Date Published | 2008 Jul |
| ISSN | 1523-6536 |
| Keywords | Aged, Antigens, CD34, Antineoplastic Combined Chemotherapy Protocols, Clarithromycin, Cyclophosphamide, Dexamethasone, Drug Therapy, Combination, Female, Granulocyte Colony-Stimulating Factor, Hematinics, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Multiple Myeloma, Remission Induction, Stem Cells, Thalidomide, Transplantation, Autologous, Treatment Outcome |
| Abstract | A total of 28 treatment-naïve patients with stage II or III multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33% mobilized with G-CSF alone (P < .0001). The duration of prior lenalidomide therapy did not correlate with success of stem cell harvests (P = .91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide. |
| DOI | 10.1016/j.bbmt.2008.04.008 |
| Alternate Journal | Biol. Blood Marrow Transplant. |
| PubMed ID | 18541199 |
| PubMed Central ID | PMC3626097 |
| Grant List | K23 CA109260 / CA / NCI NIH HHS / United States UL1 RR024996 / RR / NCRR NIH HHS / United States K23 CA109260-01 / CA / NCI NIH HHS / United States |